Research Scientist II or Senior Scientist I- Toxicology (80-100%) (Dual Level Posting)

Das ist der Job

Please include the job requisition number in your message. /p /p #J-18808-Ljbffr

Darum lohnt es sich

ph3Summary /h3 p#LI-Onsitebr/Location: Baselbr/Internal Title: Research Scientist II or Senior Scientist I /p pWe are seeking a highly motivated Associate Scientist to join a multidisciplinary team working on genome safety assessment for advanced therapies.

This position offers the opportunity to contribute to cutting‑edge research addressing integration risk and tumorigenicity in a highly collaborative environment interfacing with regulatory, nonclinical, and translational teams. /p h3About the Role /h3 pbKey responsibilities /b /p ul liConduct in vitro studies to support genotoxicity assessment of gene therapies (AAVs, lentiviruses, etc) for regulatory use /li liSupport mechanistic evaluation of genome integrity following gene therapy modalities /li liGenerate, analyze, and interpret experimental data to support nonclinical safety assessments /li liContribute to integration site analysis (ISA) strategies and interpretation /li liDesign and execute cell‑based assays to investigate DNA damage and mechanisms responsible to viral integration /li liDevelop and implement state‑of‑the‑art innovative technologies and systems for regulatory and investigative genetic toxicity testing across all therapeutic areas and modalities /li liCollaborate with internal experts and external partners to align on study design and data interpretation /li liDocument and communicate results in reports, presentations, and regulatory‑relevant summaries /li /ul pbEssential Requirements: /b /p ul liMaster degree in cellular biology, molecular biology, toxicology or a related subject.

The final level title of the offer role would be determined by the hiring team based on the skills, experience capabilities required for the role. /p h3Benefits Rewards /h3 pAt Novartis, we’re committed to reimagining medicine together and rewarding the people who make it happen. /p pExpected Annual Base Salary Range: 65,870.00 – 122,330.00 CHF Annual. /p pThe base salary offered is determined based on gender‑neutral objectives and will be reviewed periodically.

In addition, you may be eligible for a performance‑based bonus and long‑term equity awards at group level. /p pAdditional benefits include insurance plans, retirement plans, wellbeing resources, global recognition programs, flexible and hybrid working options where possible, and a minimum of 14 weeks paid parental leave. /p pBenefits and compensation may vary by country and are subject to local legal requirements. /p pRead our brochure to learn more about our global total rewards offering: /p pbCommitment to Diversity and Inclusion / EEO /b /p pNovartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve. /p pbAccessibility and accommodation /b /p pNovartis is committed to working with and providing reasonable accommodation to all individuals.

The role focuses on studies supporting the genotoxicity assessment of gene and cell therapies, including AAV-based approaches and CAR‑T platforms.

No PhD. /li liExperience with mammalian cell culture (primary cells and established cell lines) /li liMolecular biology: DNA/RNA extraction, PCR based methods, library preparation for sequencing /li liBasic programming skills for data analysis (R, Python, etc) /li liStrong data interpretation skills and attention to detail /li liAbility to work independently and collaboratively in a cross‑functional environment /li liEffective communication skills: presenting, manuscript preparation, and collaboration /li liA proactive, flexible mindset and enthusiasm for tackling non‑routine scientific challenges /li liAbility to comply with Good Laboratory Science standards, Safety, Health and Environment standards /li /ul pbDesirable /b /p ul liExperience with gene therapy systems (e.g.

AAV, lentiviral vectors, CRISPR/Cas9) /li liCRISPR/Cas9 editing /li liExperience with DNA damage/repair readouts (e.g. γH2AX, western blot, immunofluorescence, flow cytometry) /li liKaryotyping, molecular karyotyping, advanced cytogenetics (FISH, SKY) /li liFamiliarity with genome safety concepts (integration, clonal expansion, tumorigenicity) /li liExposure to primary human cells (e.g. hepatocytes) and/or advanced in vitro models /li liUnderstanding of regulatory context for nonclinical safety /li /ul pThis is a dual posting.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process or to receive more detailed information about the essential functions of this position, please send an e‑mail to E‑Mail schreiben and let us know the nature of your request and your contact information.