Remote Principal Scientist - Drug Discovery

About the Role

Our client is seeking a highly accomplished Principal Scientist with extensive experience in Drug Discovery to lead critical research initiatives on a fully remote basis. This senior position requires a strategic thinker capable of driving projects from target identification through lead optimization, leveraging deep scientific expertise and a proven track record of success. You will collaborate with a global team of scientists, manage research projects, and contribute to the company's pipeline of innovative therapeutics, all from your chosen location, without needing to be physically present in Polokwane .

Key Responsibilities

• Lead and mentor multidisciplinary drug discovery teams in the design and execution of research programs.
• Oversee target identification, validation, and hit-to-lead optimization processes.
• Develop and implement innovative strategies to advance drug candidates through the discovery pipeline.
• Analyze complex biological data, interpret results, and make data-driven decisions for project progression.
• Collaborate with internal and external partners, including academic institutions and CROs.
• Author research reports, regulatory documents, and scientific publications.

Requirements

• Ph.D. in Pharmacology, Medicinal Chemistry, Molecular Biology, or a related life science discipline.
• Minimum of 10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry.
• Demonstrated success in leading discovery programs and bringing drug candidates to preclinical development.
• Expertise in a relevant therapeutic area and modality (e.g., small molecules, biologics).
• Strong understanding of pharmacokinetic, pharmacodynamic, and toxicology principles.
• Exceptional leadership, communication, and project management skills for a remote environment.

Benefits

• Highly competitive salary and executive-level compensation package.
• Comprehensive benefits including premium health coverage and retirement plans.
• Significant bonus potential tied to company and personal performance milestones.
• Opportunities for impactful leadership and shaping the future of drug discovery.
• Exceptional work-life balance and the flexibility of a fully remote position.